Publications – Martin Lévesque Laboratory

Julia Obergasteiger, Anne-Marie Castonguay, Sara Pizzi, Stefano Magnabosco, Giulia Frapporti, Evy Lobbestael, Veerle Baekelandt, Andrew A. Hicks, Peter P. Pramstaller, Claude Gravel, Corrado Corti, Martin Lévesque & Mattia Volta. The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology. npj Parkinsons Dis. 9, 44 (2023). doi.org/10.1038/s41531-023-00484-2

Quessy F, Bittar T, Blanchette LJ, Lévesque M, Labonté B Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways. . Sci Rep. 2021 May 26;11(1):11000. doi: 10.1038/s41598-021-90521-y.

Gilmozzi V, Gentile G, Castelo Rueda MP, Hicks AA, Pramstaller PP, Zanon A, Lévesque M, Pichler I. Interaction of Alpha-Synuclein With Lipids: Mitochondrial Cardiolipin as a Critical Player in the Pathogenesis of Parkinson’s Disease. Front Neurosci. 2020 Oct 6;14:578993. doi: 10.3389/fnins.2020.578993

Castonguay AM, Gravel C, Lévesque M.Treating Parkinson’s Disease with Antibodies: Previous Studies and Future Directions J Parkinsons Dis. 2020 Oct 22. doi: 10.3233/JPD-202221.

Awatramani R, Lévesque M. “The One Who Guides” Nigral Neuron Migration. Neuron. 2020 Aug 19;107(4):595-596. doi: 10.1016/j.neuron.2020.07.030.

Cardoso T. and Lévesque M. Toward Generating Subtype-Specific Mesencephalic Dopaminergic Neurons in vitro. 2020 Front. Cell Dev. Biol., 17 June 2020 | doi:10.3389/fcell.2020.00443.

Salesse C, Charest J, Doucet-Beaupré H, Castonguay AM, Labrecque S, De Koninck P and Lévesque M. Opposite control of excitatory and inhibitory synapse formation by Slitrk2 and Slitrk5 on midbrain dopamine neurons modulates hyperactivity behavior. (2020) Cell Report. 30 (7):P2374-2386. E5, doi:10.1016/j.celrep.2020.01.084.

Gan-Or Z, Rao T, Leveille E, Degroot C, Chouinard S, Cicchetti F, Dagher A, Das S, Desautels A, Drouin-Ouellet J, Durcan T, Gagnon JF, Genge A, Karamchandani J, Lafontaine AL, Sun SLW, Langlois M, Levesque M, Melmed C, Panisset M, Parent M, Poline JB, Postuma RB, Pourcher E, Rouleau GA, Sharp M, Monchi O, Dupré N, Fon EA. (2020) The Quebec Parkinson Network: A Researcher-Patient Matching Platform and Multimodal Biorepository. J Parkinsons Dis. 2020;10(1):301-313. doi: 10.3233/JPD-191775.

Ben Youssef S, Brisson G, Doucet-Beaupré H, Castonguay AM, Gora C, Amri M, Lévesque M. Neuroprotective benefits of grape seed and skin extract in a mouse model of Parkinson’s disease. Nutr Neuroscience. (2019) May 25:1-15. doi: 10.1080/1028415X.2019.1616435.

Sanz RL, Ferraro GB, Kacervosky J, Salesse C, Gowing E, Hua L, Rambaldi I, Beaubien F, Holmbeck K, Cloutier JF, Lévesque M, Murai K, Fournier AE. (2018) MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding. Journal of Neuroscience. 2018 Jan 17;38(3):518-529.

Chabrat A, Brisson G, Doucet-Beaupré H, Salesse C, Profes MS, Dovonou A, Akitegetse C, Charest J, Lemstra S, Cote D, Pasterkamp RJ, Abrudan M, Metzakopian E, Ang SL, Lévesque M. (2017) Lma1a and Lmx1b regulate PlexinC1 expression and axon targeting of midbrain dopamine neurons. Nature Communications. DOI: 10.1038/s41467-017-01042-0.

Khan S, Stott S, Chabrat A, Truckenbrodt AM, Spencer-Dene B, Nave KA, Guillemot F, Levesque M, Ang SL. (2017) Survival of a novel subset of midbrain dopaminergic neurons projecting to the lateral septum is dependent on NeuroD proteins. Journal of Neuroscience. Jan 27. pii: 2414-16.

Doucet-Beaupre H, Gilbert C, Profes MS, Chabrat A, Pacelli C, Giguere N, Rioux V, Charest J, Deng Q, Laguna A, Ericsson J, Perlman T, Ang SL, Cicchetti F, Parent M, Trudeau LE, Lévesque M. (2016). Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons. PNAS 113(30): E4387-96.

Verwey M, Grant A, Meti N, Adye-White L, Torres-Berrío A, Rioux V, Lévesque M, Charron F, and Flores C. (2016). Mesocortical dopamine phenotypes in mice lacking the sonic hedgehog receptor Cdon. eNeuro 0009-16.2016

Law C, Profes MS, Levesque M, Kaldschmidt J, Verhage M, Kania A. (2015). Normal molecular specification and neurodegenerative disease-like death of spinal neurons lacking the SNARE- associated synaptic protein Munc18-1. Journal of Neuroscience. 36(2): 561-576.

Doucet-Beaupré H, Ang SL, Lévesque M. (2015). Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b. FEBS Letters. 589: 3727-38.

Pacelli C, Giguère N, Bourque MJ, Lévesque M, Slack RS, Trudeau LÉ. (2015). Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons. Current Biology. 25(18): 2349-60.

Drouin-Ouellet J, Gibrat C, Saint-Pierre M, Lagacé M, Badrinarayanan S, Lavallée-Bourget MH, Charest J, Chabrat A, Boivin L, Lebel M, Bousquet M, Lévesque M, Cicchetti F. (2015). Cystamine/cysteamine rescue the dopaminergic system and show neurorestorative properties in animal models of Parkinson’s disease.Neurobiology of Disease. 82: 430-444.

Chabrat A*, Doucet-Beaupré H*, Lévesque M. (2015). RNA isolation from cell specific subpopulations using laser-capture microdissection combined with rapid immunolabeling. JOVE. 98(Apr 11): 10.3791/52510. *Co-premier.

Pelletier SJ, Lagacé M, St-Amour M, Arsenault D, Fecteau S, Chabrat A, Levesque M, Cicchetti F. (2014). The morphological and molecular changes of brain cells exposed to direct current electric field stimulation. The International Journal of Neuropsychopharmacology. 18(5): 1-16.

Mille F*, Tamayo-Orrego L*, Lévesque M*, Remke M, Korshunov A, Cardin J, Bouchard N, Izzi L, Kool M, Northcott PA, Taylor MD, Pfister SM and Charron F.(2014). The Shh Receptor Boc Promotes Progression of Early Medulloblastoma to Advanced Tumors. Developmental Cell. 31(1): 37-47. *Co-premier.

Doucet-Beaupré H*, Lévesque M. (2013). The role of developmental transcription factors in adult midbrain dopaminergic neurons. Open Access Neurosciences. 1(1): 1-13.

Yan CH* , Levesque M* , Claxton S , Johnson RL , Ang SL. (2011). Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors. The Journal of Neuroscience. 31(35): 12413–12425. *Co-premier.

Izzi L*, Lévesque M*, Morin S , Laniel D, Wilkes BC , Mille F , Krauss RS , McMahon AP, Allen BL , Charron F. (2011). Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Developmental Cell. 20(6): 788-801. *Co-premier.

Castonguay AM, Gravel C, Lévesque M.Treating Parkinson’s Disease with Antibodies: Previous Studies and Future Directions J Parkinsons Dis. 2020 Oct 22. doi: 10.3233/JPD-202221.

Awatramani R, Lévesque M. “The One Who Guides” Nigral Neuron Migration. Neuron. 2020 Aug 19;107(4):595-596. doi: 10.1016/j.neuron.2020.07.030.

Cardoso T. and Lévesque M. Toward Generating Subtype-Specific Mesencephalic Dopaminergic Neurons in vitro. 2020 Front. Cell Dev. Biol., 17 June 2020 | doi:10.3389/fcell.2020.00443.

Doucet-Beaupré H, Gilbert C, Pacelli C, Giguere N, Rioux V, Profes MS, Charest J, Chabrat A, Deng Q, Laguna A, Ericson J, Perlmann T, Ang SL, Cicchetti F, Parent M, Trudeau LE, Lévesque M. (2016). Transcription factors Lmx1a and Lmx1b actively regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons. PNAS. 113(30): E4387-96.

Verwey M, Grant A, Meti N, Adye-White L, Torres-Berrío A, Rioux V, Lévesque M, Charron F, Flores C. (2016). Mesocortical Dopamine Phenotypes in Mice Lacking the Sonic Hedgehog Receptor Cdon. eNeuro 0009-16.2016.

Cisbani G, Drouin-Ouellet J, Gibrat C, Saint-Pierre M, Lagacé M, Badrinarayanan S, Lavallée-Bourget MH, Charest J, Chabrat A, Boivin L, Lebel M, Bousquet M, Lévesque M, Cicchetti F. (2015) Cystamine/cysteamine rescues the dopaminergic system and shows neurorestorative properties in an animal model of Parkinson’s disease. Neurobiology of disease 82, 430-444.

Chabrat A, Doucet-Beaupré H, Lévesque M. (2015). RNA isolation from cell specific subpopulations using laser-capture microdissection combined with rapid immunolabeling. JoVE 98(Apr 11): 10.3791/52510.

Law C, Profes MS, Lévesque M, Kaldschmidt J, Verhage M, Kania A. (2015). Normal molecular specification and neurodegenerative disease-like death of spinal neurons lacking the SNARE-associated synaptic protein Munc18-1. Journal of Neuroscience. 36(2): 561-576.

Pacelli C, Giguère N, Bourque MJ, Lévesque M, Slack RS, Trudeau LÉ (2015). Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons. Current Biology. 25(18): 2349-60.

Lévesque M*, Mille F*, Tamayo-Orrego L*, Remke M, Korshunov A, Cardin J, Bouchard N, Izzi L, Kool M, Northcott PA, Taylor MD, Pfister SM, Charron F. (2014) The Shh Receptor Boc Promotes Progression of Early Medulloblastoma to Advanced Tumors. Developmental Cell 31 (1), 34-47. *Equal contributions.

Pelletier SJ, Lagacé M, St-Amour M, Arsenault D, Fecteau S, Chabrat A, Lévesque M, Cicchetti F. (2014). The morphological and molecular changes of brain cells exposed to direct current electric field stimulation. The International Journal of Neuropsychopharmacology. 18(5): 1-16.

Doucet-Beaupré H and Lévesque M. The role of developmental transcription factors in adult midbrain dopaminergic neurons. OA Neurosciences Oct 01;1(1):3, 2013.

Lévesque M*, Yan C*, Claxton S, Johnson RL and Ang SL. (2011) Lmx1a and Lmx1b function cooperatively to regulate proliferation, specification and differentiation of mesodiencephalic dopaminergic progenitors. J. Neuroscience 31(35):12413-25, *Equal contributions.

Lévesque M*, Izzi L*, Morin S, Laniel D, Wilkes BC, Mille F, Krause R, McMahon A, Allen BJ, Charron F. Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Developmental Cell 20(6):788-801,2011. *Equal contributions.

Huot P, Lévesque M, Morissette M, Calon F, Dridi M, Di Paolo T, Parent A. (2008). L-Dopa treatment abolishes the numerical increase in striatal dopaminergic neurons in parkinsonian monkeys. Journal of chemical neuroanatomy. 35(1).

Huot P, Lévesque M, Parent A. (2007). The fate of striatal dopaminergic neurons in Parkinson’s disease and Huntington’s chorea. Brain 130(Pt 1).

Lévesque M, Wallman MJ , Parent R , Sík A , Parent A. (2007). Neurokinin-1 and neurokinin-3 receptors in primate substantia nigra. Neuroscience research. 57(3).

Lévesque M, Parent R, Parent A. (2006). Cellular and subcellular localization of neurokinin-1 and neurokinin-3 receptors in primate globus pallidus. The European journal of neuroscience. 23(10).

Lévesque M, Parent A. (2005). The striatofugal fiber system in primates: a reevaluation of its organization based on single-axon tracing studies. PNAS 102(33).
Lévesque M, Wallman MJ, Parent A. (2004). Striosomes are enriched in glutamic acid decarboxylase in primates. Neuroscience research. 50(1).

Lévesque M, Bédard A, Cossette M, Parent A. (2003). Novel aspects of the chemical anatomy of the striatum and its efferents projections. Journal of chemical neuroanatomy. 26(4).

Bédard A, Lévesque M, Bernier PJ, Parent A. (2002). The rostral migratory stream in adult squirrel monkeys: contribution of new neurons to the olfactory tubercle and involvement of the antiapoptotic protein Bcl-2. The European journal of neuroscience. 16(10).

Bédard A, Cossette M, Lévesque M, Parent A. (2002). Proliferating cells can differentiate into neurons in the striatum of normal adult monkey. Neuroscience letters. 328(3).

Bernier PJ, Bedard A, Vinet J, Lévesque M, Parent A. (2002). Newly generated neurons in the amygdala and adjoining cortex of adult primates. PNAS. 99(17).

Parent M, Lévesque M, Parent A. (2001). Two types of projection neurons in the internal pallidum of primates: single-axon tracing and three-dimensional reconstruction. The Journal of comparative neurology. 439(2).

Parent A, Lévesque M, Parent M. (2001). A re-evaluation of the current model of the basal ganglia. Parkinsonism & related disorders. 7(3).

Sato F, Lavallée P, Lévesque M, Parent A. (2000). Single-axon tracing study of neurons of the external segment of the globus pallidus in primate. The Journal of comparative neurology. 417(1).

Parent A, Sato F, Wu Y, Gauthier J, Lévesque M, Parent M. (2000). Organization of the basal ganglia: the importance of axonal collateralization. Trends in neurosciences. 23(10 Suppl).

Sato F, Parent M, Lévesque M, Parent A. (2000). Axonal branching pattern of neurons of the subthalamic nucleus in primates. The Journal of comparative neurology. 424(1).

Gauthier J, Parent M, Lévesque M, Parent A. (1999). The axonal arborization of single nigrostriatal neurons in rats. Brain Research. 834(1-2).

Cossette M, Lévesque M, Parent A. (1999). Extrastriatal dopaminergic innervation of human basal ganglia. Neuroscience research. 34(1).

Parent M, Lévesque M, Parent A. (1999). The pallidofugal projection system in primates: evidence for neurons branching ipsilaterally and contralaterally to the thalamus and brainstem. Journal of chemical neuroanatomy. 16(3).

Lévesque M, Charara A, Gagnon S, Parent A, Deschenes M. (1996). Corticostriatal projections from layer V cells in rat are collaterals of long-range corticofugal axons. Brain research. 709(2).

Lévesque M, Gagnon S, Parent A, Deschênes. (1996). Axonal arborizations of corticostriatal and corticothalamic fibers arising from the second somatosensory area in the rat. Cerebral cortex 6(6).

Lévesque M, Parent A. (1996). Axonal arborization of corticostriatal and corticothalamic fibers arising from prelimbic cortex in the rat. Cerebral cortex. 8(7).